A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

ανά Brooun, Alexei, Liu, Songhua, Lewis, Kim
Έκδοση 2000

Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter

ανά Brooun, Alexei, Tomashek, John J., Lewis, Kim
Έκδοση 1999

Sensory Rhodopsin II Transducer HtrII Is Also Responsible for Serine Chemotaxis in the Archaeon Halobacterium salinarum

ανά Hou, Shaobin, Brooun, Alexei, Suk Yu, Hyung, Freitas, Tracey, Alam, Maqsudul
Έκδοση 1998

An Archaeal Aerotaxis Transducer Combines Subunit I Core Structures of Eukaryotic Cytochrome c Oxidase and Eubacterial Methyl-Accepting Chemotaxis Proteins

ανά Brooun, Alexei, Bell, James, Freitas, Tracey, Larsen, Randy W., Alam, Maqsudul
Έκδοση 1998

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

ανά Johnson, Ted W., Gallego, Rebecca A., Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele
Τόπος έκδοσης ACS Med Chem Lett (2018)

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

ανά Chen, Ping, Deng, Ya-Li, Bergqvist, Simon, Falk, Matthew D, Liu, Wei, Timofeevski, Sergei, Brooun, Alexei
Τόπος έκδοσης Protein Sci (2014)

The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

ανά Ye, Sheng, von Delft, Frank, Brooun, Alexei, Knuth, Mark W., Swanson, Ronald V., McRee, Duncan E.
Έκδοση 2003

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

ανά Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Έκδοση 2014

Homo-dimerization of the PAS-B Domains of Hypoxia-Inducible Factors

ανά Zhu, Jing, Martinez-Yamout, Maria, Cardoso, Rosa, Yan, Jiangli, Love, Robert A., Grodsky, Neil, Brooun, Alexei, Dyson, H. Jane
Έκδοση 2012

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

ανά Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Τόπος έκδοσης ACS Med Chem Lett (2018)

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

ανά Chrencik, Jill E., Brooun, Alexei, Recht, Michael I., Nicola, George, Davis, Leila K., Abagyan, Ruben, Widmer, Hans, Pasquale, Elena B., Kuhn, Peter
Τόπος έκδοσης J Biol Chem (2007)

Remedial Strategies in Structural Proteomics: Expression, Purification and Crystallization of the Vav1/Rac1 Complex

ανά Brooun, Alexei, Foster, Scott A., Chrencik, Jill E., Chien, Ellen Y.T., Kolatkar, Anand R., Streiff, Markus, Ramage, Paul, Widmer, Hans, Weckbecker, Gisbert, Kuhn, Peter
Έκδοση 2006

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

ανά Mol, Clifford D., Brooun, Alexei, Dougan, Douglas R., Hilgers, Mark T., Tari, Leslie W., Wijnands, Robert A., Knuth, Mark W., McRee, Duncan E., Swanson, Ronald V.
Έκδοση 2003

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

ανά Joseph, Jeremiah S., Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W., Brooun, Alexei, Griffith, Mark, Moy, Kin, Yadav, Maneesh K., Velasquez, Jeffrey, Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Έκδοση 2006

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

ανά Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Τόπος έκδοσης eLife (2017)

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein–protein interaction

ανά Cardoso, Rosa, Love, Robert, Nilsson, Carol L, Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K-C, Zhu, Jing, Chen, Ping, Deng, Ya-Li, Dyson, H Jane, Greig, Michael J, Brooun, Alexei
Έκδοση 2012

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

ανά Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Τόπος έκδοσης Nat Commun (2016)

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

ανά Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Έκδοση 2008

Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

ανά Wu, Beili, Chien, Ellen Y.T., Mol, Clifford D., Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J., Kuhn, Peter, Handel, Tracy M., Cherezov, Vadim, Stevens, Raymond C.
Έκδοση 2010

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

ανά Hanson, Michael A., Brooun, Alexei, Baker, Kent A., Jaakola, Veli-Pekka, Roth, Chris, Chien, Ellen, Alexandrov, Alexander, Velasquez, Jeffrey, Davis, Leila, Griffith, Mark, Moy, Kin, Ganser-Pornillos, Barbie, Kuhn, Peter, Ellis, Sam, Yeager, Mark, Stevens, Raymond C.
Έκδοση 2007