Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia

por Mezzatesta, Caterina, Bornhauser, Beat C.
Publicado en Front Cell Dev Biol (2019)

Tissue Expression and Actin Binding of a Novel N-Terminal Utrophin Isoform

por Zuellig, Richard A., Bornhauser, Beat C., Amstutz, Ralf, Constantin, Bruno, Schaub, Marcus C.
Publicado 2011

Rapid Generation of Leukemogenic Chromosomal Translocations in Vivo Using CRISPR/Cas9

por Huang, Yun, Marovca, Blerim, Dettwiler, Susanne, Bode, Peter Karl, Bornhauser, Beat, Bourquin, Jean-Pierre
Publicado en Hemasphere (2020)

PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E(3)-ligase MIR

por Nagano, Kohji, Bornhauser, Beat C, Warnasuriya, Gayathri, Entwistle, Alan, Cramer, Rainer, Lindholm, Dan, Naaby-Hansen, Soren
Publicado 2006

Venetoclax and Bortezomib in Relapsed/Refractory Early T-Cell Precursor Acute Lymphoblastic Leukemia

por La Starza, Roberta, Cambò, Benedetta, Pierini, Antonio, Bornhauser, Beat, Montanaro, Anna, Bourquin, Jean-Pierre, Mecucci, Cristina, Roti, Giovanni
Publicado en JCO Precis Oncol (2019)

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

por McComb, Scott, Chan, Pik Ki, Guinot, Anna, Hartmannsdottir, Holmfridur, Jenni, Silvia, Dobay, Maria Pamela, Bourquin, Jean-Pierre, Bornhauser, Beat C.
Publicado en Sci Adv (2019)

Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacti...

por Do, Hai Thi, Tselykh, Timofey V., Mäkelä, Johanna, Ho, Tho Huu, Olkkonen, Vesa M., Bornhauser, Beat C., Korhonen, Laura, Zelcer, Noam, Lindholm, Dan
Publicado 2012

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

por Bonapace, Laura, Bornhauser, Beat C., Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K., Schäfer, Beat W., Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre
Publicado 2010

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

por Boutter, Jeannette, Huang, Yun, Marovca, Blerim, Vonderheit, Andreas, Grotzer, Michael A., Eckert, Cornelia, Cario, Gunnar, Wollscheid, Bernd, Horvath, Peter, Bornhauser, Beat C., Bourquin, Jean-Pierre
Publicado en Oncotarget (2014)

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B(12)-trafficking proteins ABCD4 and LMBD1

por Fettelschoss, Victoria, Burda, Patricie, Sagné, Corinne, Coelho, David, De Laet, Corinne, Lutz, Seraina, Suormala, Terttu, Fowler, Brian, Pietrancosta, Nicolas, Gasnier, Bruno, Bornhauser, Beat, Froese, D. Sean, Baumgartner, Matthias R.
Publicado en J Biol Chem (2017)

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres

por Walter, Dagmar, Satheesha, Sampoorna, Albrecht, Patrick, Bornhauser, Beat C., D'Alessandro, Valentina, Oesch, Susanne M., Rehrauer, Hubert, Leuschner, Ivo, Koscielniak, Ewa, Gengler, Carole, Moch, Holger, Bernasconi, Michele, Niggli, Felix K., Schäfer, Beat W.
Publicado 2011

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia

por Zaliova, Marketa, Potuckova, Eliska, Lukes, Julius, Winkowska, Lucie, Starkova, Julia, Janotova, Iveta, Sramkova, Lucie, Stary, Jan, Zuna, Jan, Stanulla, Martin, Zimmermann, Martin, Bornhauser, Beat, Bourquin, Jean-Pierre, Eckert, Cornelia, Cario, Gunnar, Trka, Jan
Publicado en Haematologica (2020)

TNFR2 is required for RIP1-dependent cell death in human leukemia

por Aguadé-Gorgorió, Júlia, McComb, Scott, Eckert, Cornelia, Guinot, Anna, Marovca, Blerim, Mezzatesta, Caterina, Jenni, Silvia, Abduli, Liridon, Schrappe, Martin, Dobay, Maria Pamela, Stanulla, Martin, von Stackelberg, Arend, Cario, Gunnar, Bourquin, Jean-Pierre, Bornhauser, Beat C.
Publicado en Blood Adv (2020)

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

por Vanden Bempt, Marlies, Demeyer, Sofie, Broux, Michaël, De Bie, Jolien, Bornschein, Simon, Mentens, Nicole, Vandepoel, Roel, Geerdens, Ellen, Radaelli, Enrico, Bornhauser, Beat C., Kulozik, Andreas E., Meijerink, Jules P., Bourquin, Jean-Pierre, de Bock, Charles E., Cools, Jan
Publicado en Cancer Cell (2018)

Repurposing anthelmintic agents to eradicate resistant leukemia

por Mezzatesta, Caterina, Abduli, Liridon, Guinot, Anna, Eckert, Cornelia, Schewe, Denis, Zaliova, Marketa, Vinti, Luciana, Marovca, Blerim, Tsai, Yi-Chien, Jenni, Silvia, Aguade-Gorgorio, Julia, von Stackelberg, Arend, Schrappe, Martin, Locatelli, Franco, Stanulla, Martin, Cario, Gunnar, Bourquin, Jean-Pierre, Bornhauser, Beat C.
Publicado en Blood Cancer J (2020)

Pharmacological disruption of the Notch transcription factor complex

por Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy
Publicado en Proc Natl Acad Sci U S A (2020)

Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 Against Pediatric Acute Lymphoblastic Leukemia Xenografts

por Suryani, Santi, Carol, Hernan, Chonghaile, Triona Ni, Frismantas, Viktoras, Sarmah, Chintanu, High, Laura, Bornhauser, Beat, Cowley, Mark J, Szymanska, Barbara, Evans, Kathryn, Boehm, Ingrid, Tonna, Elise, Jones, Luke, Manesh, Donya Moradi, Kurmasheva, Raushan T., Billups, Catherine, Kaplan, Warren, Letai, Anthony, Bourquin, Jean-Pierre, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B
Publicado 2014

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo

por Jyotsana, Nidhi, Sharma, Amit, Chaturvedi, Anuhar, Scherr, Michaela, Kuchenbauer, Florian, Sajti, Laszlo, Barchanski, Annette, Lindner, Robert, Noyan, Fatih, Sühs, Kurt-Wolfram, Grote-Koska, Denis, Brand, Korbinian, Vornlocher, Hans-Peter, Stanulla, Martin, Bornhauser, Beat, Bourquin, Jean-Pierre, Eder, Matthias, Thol, Felicitas, Ganser, Arnold, Humphries, R. Keith, Ramsay, Euan, Cullis, Pieter, Heuser, Michael
Publicado en Leukemia (2017)

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

por Seyfried, Felix, Demir, Salih, Hörl, Rebecca Louise, Stirnweiß, Felix Uli, Ryan, Jeremy, Scheffold, Annika, Villalobos-Ortiz, Mariana, Boldrin, Elena, Zinngrebe, Julia, Enzenmüller, Stefanie, Jenni, Silvia, Tsai, Yi-Chien, Bornhauser, Beat, Fürstberger, Axel, Kraus, Johann Michael, Kestler, Hans Armin, Bourquin, Jean-Pierre, Stilgenbauer, Stephan, Letai, Anthony, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Publicado en Cell Death Dis (2019)

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

por Bhansali, Rahul S., Rammohan, Malini, Lee, Paul, Laurent, Anouchka P., Wen, Qiang, Suraneni, Praveen, Yip, Bon Ham, Tsai, Yi-Chien, Jenni, Silvia, Bornhauser, Beat, Siret, Aurélie, Fruit, Corinne, Pacheco-Benichou, Alexandra, Harris, Ethan, Besson, Thierry, Thompson, Benjamin J., Goo, Young Ah, Hijiya, Nobuko, Vilenchik, Maria, Izraeli, Shai, Bourquin, Jean-Pierre, Malinge, Sébastien, Crispino, John D.
Publicado en J Clin Invest (2021)