Pharmacological disruption of the Notch transcription factor complex

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies against Notch ligands and receptors, as wel...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368267/
https://ncbi.nlm.nih.gov/pubmed/32601208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922606117
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