Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

The LDLR is a critical factor in the regulation of blood cholesterol levels that are altered in different human diseases. The level of LDLR in the cell is regulated by both transcriptional and post-transcriptional events. The E3 ubiquitin ligase, myosin regulatory light chain-interacting protein (My...

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Autors principals: Do, Hai Thi, Tselykh, Timofey V., Mäkelä, Johanna, Ho, Tho Huu, Olkkonen, Vesa M., Bornhauser, Beat C., Korhonen, Laura, Zelcer, Noam, Lindholm, Dan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339997/
https://ncbi.nlm.nih.gov/pubmed/22378787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341248
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