Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

We recently identified the liver X receptor-regulated E3 ubiquitin ligase inducible degrader of the LDL receptor (IDOL) as a modulator of lipoprotein metabolism. Acting as an E3 ubiquitin ligase, IDOL triggers ubiquitination and subsequent degradation of the low density lipoprotein receptor (LDLR)....

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Detalhes bibliográficos
Main Authors: Sorrentino, Vincenzo, Scheer, Lilith, Santos, Ana, Reits, Eric, Bleijlevens, Boris, Zelcer, Noam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191058/
https://ncbi.nlm.nih.gov/pubmed/21734303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249557
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