A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic dysregulation of these processes is associated with pathological conditions, most notably cardiovascular disease. Using a genetic approach, we have...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Cell Biol
Главные авторы: Loregger, Anke, Cook, Emma Claire Laura, Nelson, Jessica Kristin, Moeton, Martina, Sharpe, Laura Jane, Engberg, Susanna, Karimova, Madina, Lambert, Gilles, Brown, Andrew John, Zelcer, Noam
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719299/
https://ncbi.nlm.nih.gov/pubmed/26527619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00890-15
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы