The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

The mevalonate pathway is used by cells to produce sterol and nonsterol metabolites and is subject to tight metabolic regulation. We recently reported that squalene monooxygenase (SM), an enzyme controlling a rate-limiting step in cholesterol biosynthesis, is subject to cholesterol-dependent proteas...

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Main Authors: Zelcer, Noam, Sharpe, Laura J., Loregger, Anke, Kristiana, Ika, Cook, Emma C. L., Phan, Lisa, Stevenson, Julian, Brown, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993563/
https://ncbi.nlm.nih.gov/pubmed/24449766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01140-13
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