A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic dysregulation of these processes is associated with pathological conditions, most notably cardiovascular disease. Using a genetic approach, we have...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Loregger, Anke, Cook, Emma Claire Laura, Nelson, Jessica Kristin, Moeton, Martina, Sharpe, Laura Jane, Engberg, Susanna, Karimova, Madina, Lambert, Gilles, Brown, Andrew John, Zelcer, Noam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719299/
https://ncbi.nlm.nih.gov/pubmed/26527619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00890-15
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