Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to other post-translational modifications, ubiquityl...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nelson, Jessica Kristine, Cook, Emma Clare Laura, Loregger, Anke, Hoeksema, Marten Anne, Scheij, Saskia, Kovacevic, Igor, Hordijk, Peter Lodewijk, Ovaa, Huib, Zelcer, Noam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813502/
https://ncbi.nlm.nih.gov/pubmed/26719329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698688
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