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LXR Regulates Cholesterol Uptake through Idol-dependent Ubiquitination of the LDL Receptor
Cellular cholesterol levels reflect a balance between uptake, efflux and endogenous synthesis. Here we show that the sterol-responsive nuclear receptor LXR helps maintain cholesterol homeostasis not only through promotion of cholesterol efflux, but also through suppression of low-density lipoprotein...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777523/ https://ncbi.nlm.nih.gov/pubmed/19520913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1168974 |
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