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LXR Regulates Cholesterol Uptake through Idol-dependent Ubiquitination of the LDL Receptor

Cellular cholesterol levels reflect a balance between uptake, efflux and endogenous synthesis. Here we show that the sterol-responsive nuclear receptor LXR helps maintain cholesterol homeostasis not only through promotion of cholesterol efflux, but also through suppression of low-density lipoprotein...

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Autori principali: Zelcer, Noam, Hong, Cynthia, Boyadjian, Rima, Tontonoz, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777523/
https://ncbi.nlm.nih.gov/pubmed/19520913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1168974
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