The LXR–Idol axis differentially regulates plasma LDL levels in primates and mice

The LXR-regulated E3 ubiquitin ligase IDOL controls LDLR receptor stability independent of SREBP and PCSK9, but its relevance to plasma lipid levels is unknown. Here we demonstrate that the effects of the LXR–IDOL axis are both tissue- and species-specific. In mice, LXR agonist induces Idol transcri...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Hong, Cynthia, Marshall, Stephanie M., McDaniel, Allison L., Graham, Mark, Layne, Joseph D., Cai, Lei, Scotti, Elena, Boyadjian, Rima, Kim, Jason, Chamberlain, Brian T., Tangirala, Rajendra K., Jung, Michael E., Fong, Loren, Lee, Richard, Young, Stephen G., Temel, Ryan E., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261644/
https://ncbi.nlm.nih.gov/pubmed/25440061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.10.001
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