The LXR–Idol axis differentially regulates plasma LDL levels in primates and mice

The LXR-regulated E3 ubiquitin ligase IDOL controls LDLR receptor stability independent of SREBP and PCSK9, but its relevance to plasma lipid levels is unknown. Here we demonstrate that the effects of the LXR–IDOL axis are both tissue- and species-specific. In mice, LXR agonist induces Idol transcri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Metab
Autores principales: Hong, Cynthia, Marshall, Stephanie M., McDaniel, Allison L., Graham, Mark, Layne, Joseph D., Cai, Lei, Scotti, Elena, Boyadjian, Rima, Kim, Jason, Chamberlain, Brian T., Tangirala, Rajendra K., Jung, Michael E., Fong, Loren, Lee, Richard, Young, Stephen G., Temel, Ryan E., Tontonoz, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261644/
https://ncbi.nlm.nih.gov/pubmed/25440061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.10.001
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares