Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

Previously, we identified the E3 ubiquitin ligase Idol (inducible degrader of the low-density lipoprotein [LDL] receptor [LDLR]) as a posttranscriptional regulator of the LDLR pathway. Idol stimulates LDLR degradation through ubiquitination of its C-terminal domain, thereby limiting cholesterol upta...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Scotti, Elena, Hong, Cynthia, Yoshinaga, Yuko, Tu, Yiping, Hu, Yan, Zelcer, Noam, Boyadjian, Rima, de Jong, Pieter J., Young, Stephen G., Fong, Loren G., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133228/
https://ncbi.nlm.nih.gov/pubmed/21343340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01469-10
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados