IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

The low-density lipoprotein receptor (LDLR) is a critical determinant of plasma cholesterol levels that internalizes lipoprotein cargo via clathrin-mediated endocytosis. Here, we show that the E3 ubiquitin ligase IDOL stimulates a previously unrecognized, clathrin-independent pathway for LDLR intern...

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Detalhes bibliográficos
Main Authors: Scotti, Elena, Calamai, Martino, Goulbourne, Chris N., Zhang, Li, Hong, Cynthia, Lin, Ron R., Choi, Jinkuk, Pilch, Paul F., Fong, Loren G., Zou, Peng, Ting, Alice Y., Pavone, Francesco S., Young, Stephen G., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624246/
https://ncbi.nlm.nih.gov/pubmed/23382078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01716-12
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