IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

The low-density lipoprotein receptor (LDLR) is a critical determinant of plasma cholesterol levels that internalizes lipoprotein cargo via clathrin-mediated endocytosis. Here, we show that the E3 ubiquitin ligase IDOL stimulates a previously unrecognized, clathrin-independent pathway for LDLR intern...

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Egile Nagusiak: Scotti, Elena, Calamai, Martino, Goulbourne, Chris N., Zhang, Li, Hong, Cynthia, Lin, Ron R., Choi, Jinkuk, Pilch, Paul F., Fong, Loren G., Zou, Peng, Ting, Alice Y., Pavone, Francesco S., Young, Stephen G., Tontonoz, Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2013
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624246/
https://ncbi.nlm.nih.gov/pubmed/23382078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01716-12
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