Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to other post-translational modifications, ubiquityl...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Nelson, Jessica Kristine, Cook, Emma Clare Laura, Loregger, Anke, Hoeksema, Marten Anne, Scheij, Saskia, Kovacevic, Igor, Hordijk, Peter Lodewijk, Ovaa, Huib, Zelcer, Noam
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Lipids
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813502/
https://ncbi.nlm.nih.gov/pubmed/26719329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698688
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