A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic dysregulation of these processes is associated with pathological conditions, most notably cardiovascular disease. Using a genetic approach, we have...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Biol
Asıl Yazarlar: Loregger, Anke, Cook, Emma Claire Laura, Nelson, Jessica Kristin, Moeton, Martina, Sharpe, Laura Jane, Engberg, Susanna, Karimova, Madina, Lambert, Gilles, Brown, Andrew John, Zelcer, Noam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719299/
https://ncbi.nlm.nih.gov/pubmed/26527619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00890-15
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