Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase

Cellular uptake of circulating cholesterol occurs via the low density lipoprotein receptor (LDLR). The E3 ubiquitin ligase IDOL is a mediator of LDLR degradation, with IDOL homodimerization thought to be required for its activity. To probe the possibility of modulating LDLR levels with an inhibitor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Leitch, Eilidh K., Elumalai, Nagarajan, Fridén-Saxin, Maria, Dahl, Göran, Wan, Paul, Clarkson, Paul, Valeur, Eric, Pairaudeau, Garry, Boyd, Helen, Tavassoli, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050537/
https://ncbi.nlm.nih.gov/pubmed/30079210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01186a
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados