Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a major regulator of mitochondrial functions and biogenesis, and was sugge...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Mäkelä, Johanna, Tselykh, Timofey V, Maiorana, Francesca, Eriksson, Ove, Do, Hai Thi, Mudò, Giuseppa, Korhonen, Laura T, Belluardo, Natale, Lindholm, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409609/
https://ncbi.nlm.nih.gov/pubmed/25932355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-3-2
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