Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic leukemia (ALL). Modulation of cell death regulators represents an attractive strategy for subverting such drug resistance. Here we report complete r...

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Autors principals: Bonapace, Laura, Bornhauser, Beat C., Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K., Schäfer, Beat W., Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846044/
https://ncbi.nlm.nih.gov/pubmed/20200450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39987
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