Functional Expression of a DNA-Topoisomerase IB from Cryptosporidium parvum

Por Ordóñez, César, Alfonso, Javier, Balaña-Fouce, Rafael, Ordóñez, David
Publicado em 2009

First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus

Por Carballeira, Néstor M., Montano, Nashbly, Balaña-Fouce, Rafael, Prada, Christopher Fernández
Publicado em 2009

The first total synthesis of the (±)-17-methyl-trans-4,5-methyleneoctadecanoic acid and related analogs with antileishmanial activity

Por Carballeira, Néstor M., Montano, Nashbly, Reguera, Rosa M., Balaña-Fouce, Rafael
Publicado em 2010

Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major

Por Balaña-Fouce, Rafael, García-Estrada, Carlos, Pérez-Pertejo, Yolanda, Reguera, Rosa M
Publicado em 2008

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

Por Reguera, Rosa M., Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Balaña-Fouce, Rafael
Publicado no Int J Parasitol Drugs Drug Resist (2014)

Leishmania major lacking arginase are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

Por Reguera, Rosa M., Balaña-Fouce, Rafael, Showalter, Melissa, Hickerson, Suzanne, Beverley, Stephen M.
Publicado em 2009

Deletion Study of DNA Topoisomerase IB from Leishmania donovani: Searching for a Minimal Functional Heterodimer

Por Díaz González, Rosario, Pérez Pertejo, Yolanda, Ordóñez, David, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado em 2007

Total Synthesis and Antileishmanial Activity of the Natural Occurring Acetylenic Fatty Acids 6-Heptadecynoic acid and 6-Icosynoic acid

Por Carballeira, Néstor M., Cartagena, Michelle M., Prada, Christopher Fernández, Rubio, Celia Fernández, Balaña-Fouce, Rafael
Publicado em 2009

DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery

Por García-Estrada, Carlos, Prada, Christopher Fernández, Fernández-Rubio, Celia, Rojo-Vázquez, Francisco, Balaña-Fouce, Rafael
Publicado em 2010

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

Por Balaña-Fouce, Rafael, Álvarez-Velilla, Raquel, Fernández-Prada, Christopher, García-Estrada, Carlos, Reguera, Rosa M.
Publicado no Int J Parasitol Drugs Drug Resist (2014)

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

Por Carballeira, Néstor M., Montano, Nashbly, Alvarez-Velilla, Raquel, Prada, Christopher F., Reguera, Rosa M., Balaña-Fouce, Rafael
Publicado em 2013

Identification and Characterization of the Regions Involved in the Nuclear Translocation of the Heterodimeric Leishmanial DNA Topoisomerase IB

Por Prada, Christopher F., Álvarez-Velilla, Raquel, Díaz-Gozález, Rosario, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado em 2013

First total synthesis and antileishmanial activity of (Z)-16-methyl-11-heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata

Por Carballeira, Néstor M., Montano, Nashbly, Cintrón, Gabriel A., Márquez, Carmary, Rubio, Celia Fernández, Prada, Christopher Fernández, Balaña-Fouce, Rafael
Publicado em 2010

First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones

Por Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Jiménez, Maribel, Molina, Ricardo, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado em 2014

Correction: First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones

Por Calvo-Álvarez, Estefanía, Álvarez-Velilla, Raquel, Jiménez, Maribel, Molina, Ricardo, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado no PLoS Negl Trop Dis (2016)

2-Alkynoic fatty acids inhibit Topoisomerase IB from Leishmania donovani

Por Carballeira, Néstor M., Cartagena, Michelle, Sanabria, David, Kaiser, Marcel, Tasdemir, Deniz, Prada, Christopher F., Reguera, Rosa M., Balaña-Fouce, Rafael
Publicado em 2012

First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme

Por Carballeira, Néstor M., Cartagena, Michelle, Li, Fengyu, Chen, Zhongfang, Prada, Christopher F., Calvo-Alvarez, Estefania, Reguera, Rosa M., Balaña-Fouce, Rafael
Publicado em 2012

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger are Effective Inhibitors of Topoisomerases IB

Por Carballeira, Néstor M., Montano, Nashbly, Amador, Luis A., Rodríguez, Abimael D., Golovko, Mikhail Y., Golovko, Svetlana A., Reguera, Rosa M., Álvarez-Velilla, Raquel, Balaña-Fouce, Rafael
Publicado no Lipids (2015)

Infrared Fluorescent Imaging as a Potent Tool for In Vitro, Ex Vivo and In Vivo Models of Visceral Leishmaniasis

Por Calvo-Álvarez, Estefanía, Stamatakis, Kostantinos, Punzón, Carmen, Álvarez-Velilla, Raquel, Tejería, Ana, Escudero-Martínez, José Miguel, Pérez-Pertejo, Yolanda, Fresno, Manuel, Balaña-Fouce, Rafael, Reguera, Rosa M.
Publicado no PLoS Negl Trop Dis (2015)

Indotecan (LMP400) and AM13-55: Two Novel Indenoisoquinolines Show Potential for Treating Visceral Leishmaniasis

Por Balaña-Fouce, Rafael, Prada, Christopher F., Requena, José María, Cushman, Mark, Pommier, Yves, Álvarez-Velilla, Raquel, Escudero-Martínez, José Miguel, Calvo-Álvarez, Estefania, Pérez-Pertejo, Yolanda, Reguera, Rosa M.
Publicado em 2012