First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme

The fatty acids (±)-2-methoxy-6Z-heptadecenoic acid (1), (±)-2-methoxy-6-heptadecynoic acid (2) and (±)-2-methoxyheptadecanoic acid (3) were synthesized and their inhibitory activity against the Leishmania DNA topoisomerase IB enzyme (LdTopIB) determined. Acids 1 and 2 were synthesized from 4-bromo-...

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Hauptverfasser: Carballeira, Néstor M., Cartagena, Michelle, Li, Fengyu, Chen, Zhongfang, Prada, Christopher F., Calvo-Alvarez, Estefania, Reguera, Rosa M., Balaña-Fouce, Rafael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483880/
https://ncbi.nlm.nih.gov/pubmed/23118491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1351/PAC-CON-11-10-21
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