Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major

BACKGROUND: The unusual heterodimeric leishmanial DNA topoisomerase IB consists of a large subunit containing the phylogenetically conserved "core" domain, and a small subunit harboring the C-terminal region with the characteristic tyrosine residue in the active site. RNAi silencing of any...

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Detaylı Bibliyografya
Asıl Yazarlar: Balaña-Fouce, Rafael, García-Estrada, Carlos, Pérez-Pertejo, Yolanda, Reguera, Rosa M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492870/
https://ncbi.nlm.nih.gov/pubmed/18611247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-8-113
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