Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

ανά Ayers, Jacob I., Borchelt, David R.
Τόπος έκδοσης Acta Neuropathol (2020)

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism

ανά Ayers, Jacob I., Kincaid, Anthony E., Bartz, Jason C.
Έκδοση 2009

Prion-like Spreading in Tauopathies

ανά Ayers, Jacob I., Giasson, Benoit I., Borchelt, David R.
Τόπος έκδοσης Biol Psychiatry (2017)

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

ανά Shikiya, Ronald A., Ayers, Jacob I., Schutt, Charles R., Kincaid, Anthony E., Bartz, Jason C.
Έκδοση 2010

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

ανά Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P John, Borchelt, David R
Έκδοση 2014

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

ανά Ayers, Jacob I., Fromholt, Susan E., O’Neal, Veronica M., Diamond, Jeffrey H., Borchelt, David R.
Τόπος έκδοσης Acta Neuropathol (2015)

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

ανά Crosby, Keith, Crown, Anthony M., Roberts, Brittany L., Brown, Hilda, Ayers, Jacob I., Borchelt, David R.
Τόπος έκδοσης PLoS One (2018)

The Strain-Encoded Relationship between PrP(Sc) Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

ανά Ayers, Jacob I., Schutt, Charles R., Shikiya, Ronald A., Aguzzi, Adriano, Kincaid, Anthony E., Bartz, Jason C.
Έκδοση 2011

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice

ανά Xu, Guilian, Ayers, Jacob I., Roberts, Brittany L., Brown, Hilda, Fromholt, Susan, Green, Cameron, Borchelt, David R.
Τόπος έκδοσης Hum Mol Genet (2015)

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

ανά Rasouli, Sanaz, Abdolvahabi, Alireza, Croom, Corbin M., Plewman, Devon L., Shi, Yunhua, Ayers, Jacob I., Shaw, Bryan F.
Τόπος έκδοσης J Biol Chem (2017)

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

ανά Crown, Anthony M., Roberts, Brittany L., Crosby, Keith, Brown, Hilda, Ayers, Jacob I., Hart, P. John, Borchelt, David R.
Τόπος έκδοσης G3 (Bethesda) (2019)

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

ανά Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Τόπος έκδοσης J Virol (2017)

Prion Interference Is Due to a Reduction in Strain-Specific PrP(Sc) Levels

ανά Bartz, Jason C., Kramer, Michelle L., Sheehan, Meghan H., Hutter, Jessica A. L., Ayers, Jacob I., Bessen, Richard A., Kincaid, Anthony E.
Έκδοση 2007

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

ανά Xu, Guilian, Fromholt, Susan, Ayers, Jacob I., Brown, Hilda, Siemienski, Zoe, Crosby, Keith W., Mayer, Christopher A., Janus, Christopher, Borchelt, David R.
Τόπος έκδοσης J Neurochem (2015)

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

ανά Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.
Τόπος έκδοσης Acta Neuropathol (2016)

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

ανά Ayers, Jacob I., Riffe, Cara J., Sorrentino, Zachary A., Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P. John, Giasson, Benoit I.
Τόπος έκδοσης J Virol (2018)

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

ανά Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
Τόπος έκδοσης PLoS One (2020)

Relationship between mutant SOD1 maturation and inclusion formation in cell models

ανά Ayers, Jacob I., McMahon, Benjamin, Gill, Sabrina, Lelie, Herman L., Fromholt, Susan, Brown, Hilda, Valentine, Joan Selverstone, Whitelegge, Julian P., Borchelt, David R.
Τόπος έκδοσης J Neurochem (2016)

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

ανά Ayers, Jacob I., Xu, Guilian, Dillon, Kristy, Lu, Qing, Chen, Zhijuan, Beckman, John, Moreno-Romero, Alma K., Zamora, Diana L., Galaleldeen, Ahmad, Borchelt, David R.
Τόπος έκδοσης Acta Neuropathol Commun (2021)

Non-prion type transmission in A53T α-synuclein transgenic mice: A normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

ανά Sacino, Amanda N., Ayers, Jacob I., Brooks, Mieu M.T., Chakrabarty, Paramita, Hudson, Vincent J., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I., Borchelt, David R.
Τόπος έκδοσης Acta Neuropathol (2015)