Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

per Ayers, Jacob I., Borchelt, David R.
Publicat a Acta Neuropathol (2020)

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism

per Ayers, Jacob I., Kincaid, Anthony E., Bartz, Jason C.
Publicat 2009

Prion-like Spreading in Tauopathies

per Ayers, Jacob I., Giasson, Benoit I., Borchelt, David R.
Publicat a Biol Psychiatry (2017)

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

per Shikiya, Ronald A., Ayers, Jacob I., Schutt, Charles R., Kincaid, Anthony E., Bartz, Jason C.
Publicat 2010

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

per Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P John, Borchelt, David R
Publicat 2014

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

per Ayers, Jacob I., Fromholt, Susan E., O’Neal, Veronica M., Diamond, Jeffrey H., Borchelt, David R.
Publicat a Acta Neuropathol (2015)

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

per Crosby, Keith, Crown, Anthony M., Roberts, Brittany L., Brown, Hilda, Ayers, Jacob I., Borchelt, David R.
Publicat a PLoS One (2018)

The Strain-Encoded Relationship between PrP(Sc) Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

per Ayers, Jacob I., Schutt, Charles R., Shikiya, Ronald A., Aguzzi, Adriano, Kincaid, Anthony E., Bartz, Jason C.
Publicat 2011

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice

per Xu, Guilian, Ayers, Jacob I., Roberts, Brittany L., Brown, Hilda, Fromholt, Susan, Green, Cameron, Borchelt, David R.
Publicat a Hum Mol Genet (2015)

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

per Rasouli, Sanaz, Abdolvahabi, Alireza, Croom, Corbin M., Plewman, Devon L., Shi, Yunhua, Ayers, Jacob I., Shaw, Bryan F.
Publicat a J Biol Chem (2017)

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

per Crown, Anthony M., Roberts, Brittany L., Crosby, Keith, Brown, Hilda, Ayers, Jacob I., Hart, P. John, Borchelt, David R.
Publicat a G3 (Bethesda) (2019)

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

per Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Publicat a J Virol (2017)

Prion Interference Is Due to a Reduction in Strain-Specific PrP(Sc) Levels

per Bartz, Jason C., Kramer, Michelle L., Sheehan, Meghan H., Hutter, Jessica A. L., Ayers, Jacob I., Bessen, Richard A., Kincaid, Anthony E.
Publicat 2007

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

per Xu, Guilian, Fromholt, Susan, Ayers, Jacob I., Brown, Hilda, Siemienski, Zoe, Crosby, Keith W., Mayer, Christopher A., Janus, Christopher, Borchelt, David R.
Publicat a J Neurochem (2015)

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

per Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.
Publicat a Acta Neuropathol (2016)

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

per Ayers, Jacob I., Riffe, Cara J., Sorrentino, Zachary A., Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P. John, Giasson, Benoit I.
Publicat a J Virol (2018)

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

per Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
Publicat a PLoS One (2020)

Relationship between mutant SOD1 maturation and inclusion formation in cell models

per Ayers, Jacob I., McMahon, Benjamin, Gill, Sabrina, Lelie, Herman L., Fromholt, Susan, Brown, Hilda, Valentine, Joan Selverstone, Whitelegge, Julian P., Borchelt, David R.
Publicat a J Neurochem (2016)

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

per Ayers, Jacob I., Xu, Guilian, Dillon, Kristy, Lu, Qing, Chen, Zhijuan, Beckman, John, Moreno-Romero, Alma K., Zamora, Diana L., Galaleldeen, Ahmad, Borchelt, David R.
Publicat a Acta Neuropathol Commun (2021)

Non-prion type transmission in A53T α-synuclein transgenic mice: A normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

per Sacino, Amanda N., Ayers, Jacob I., Brooks, Mieu M.T., Chakrabarty, Paramita, Hudson, Vincent J., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I., Borchelt, David R.
Publicat a Acta Neuropathol (2015)