Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation

door Assimon, Victoria A., Southworth, Daniel R., Gestwicki, Jason E.
Gepubliceerd in Biochemistry (2015)

Hsp70 Protein Complexes as Drug Targets

door Assimon, Victoria A., Gillies, Anne T., Rauch, Jennifer N., Gestwicki, Jason E.
Gepubliceerd in 2013

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity

door Assimon, Victoria A., Shao, Hao, Garneau-Tsodikova, Sylvie, Gestwicki, Jason E.
Gepubliceerd in Medchemcomm (2015)

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions

door Rinaldi, Silvia, Assimon, Victoria A., Young, Zapporah T., Morra, Giulia, Shao, Hao, Taylor, Isabelle R., Gestwicki, Jason E., Colombo, Giorgio
Gepubliceerd in ACS Chem Biol (2018)

Protein Cross-linking Capillary Electrophoresis at Increased Throughput for a Range of Protein-Protein Interactions

door Ouimet, Claire M., Dawod, Mohamed, Grinias, James, Assimon, Victoria A., Lodge, Jean, Mapp, Anna K., Gestwicki, Jason E., Kennedy, Robert T.
Gepubliceerd in Analyst (2018)

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

door Connarn, Jamie N., Assimon, Victoria A., Reed, Rebecca A., Tse, Eric, Southworth, Daniel R., Zuiderweg, Erik R. P., Gestwicki, Jason E., Sun, Duxin
Gepubliceerd in 2014

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

door Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Gepubliceerd in Hum Mol Genet (2015)

The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex

door Smith, Matthew C., Scaglione, K. Matthew, Assimon, Victoria A., Patury, Srikanth, Thompson, Andrea D., Dickey, Chad A., Southworth, Daniel R., Paulson, Henry L., Gestwicki, Jason E., Zuiderweg, Erik R.P.
Gepubliceerd in 2013

High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

door Taylor, Isabelle R., Dunyak, Bryan M., Komiyama, Tomoko, Shao, Hao, Ran, Xu, Assimon, Victoria A., Kalyanaraman, Chakrapani, Rauch, Jennifer N., Jacobson, Matthew P., Zuiderweg, Erik R. P., Gestwicki, Jason E.
Gepubliceerd in J Biol Chem (2018)

Specificity for latent C-termini links the E3 ubiquitin ligase CHIP to caspases

door Ravalin, Matthew, Theofilas, Panagiotis, Basu, Koli, Opoku-Nsiah, Kwadwo A., Assimon, Victoria A., Medina-Cleghorn, Daniel, Chen, Yi-Fan, Bohn, Markus F., Arkin, Michelle, Grinberg, Lea T., Craik, Charles S., Gestwicki, Jason E.
Gepubliceerd in Nat Chem Biol (2019)

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

door Taylor, Isabelle R., Assimon, Victoria A., Kuo, Szu Yu, Rinaldi, Silvia, Li, Xiaokai, Young, Zapporah T., Morra, Giulia, Green, Keith, Nguyen, Daniel, Shao, Hao, Garneau-Tsodikova, Sylvie, Colombo, Giorgio, Gestwicki, Jason E.
Gepubliceerd in Chem Sci (2020)

Predicting protein targets for drug-like compounds using transcriptomics

door Pabon, Nicolas A., Xia, Yan, Estabrooks, Samuel K., Ye, Zhaofeng, Herbrand, Amanda K., Süß, Evelyn, Biondi, Ricardo M., Assimon, Victoria A., Gestwicki, Jason E., Brodsky, Jeffrey L., Camacho, Carlos J., Bar-Joseph, Ziv
Gepubliceerd in PLoS Comput Biol (2018)

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

door Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh, Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George, Srinivasan, Sharan R., Zuiderweg, Erik R. P., Dickey, Chad A., Gestwicki, Jason E.
Gepubliceerd in Cell Chem Biol (2016)

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

door Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R. P., Gestwicki, Jason E., Dickey, Chad A.
Gepubliceerd in J Biol Chem (2015)

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

door Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Gepubliceerd in Nat Struct Mol Biol (2018)