High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

Protein–protein interactions (PPIs) are an important category of putative drug targets. Improvements in high-throughput screening (HTS) have significantly accelerated the discovery of inhibitors for some categories of PPIs. However, methods suitable for screening multiprotein complexes (e.g. those c...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Taylor, Isabelle R., Dunyak, Bryan M., Komiyama, Tomoko, Shao, Hao, Ran, Xu, Assimon, Victoria A., Kalyanaraman, Chakrapani, Rauch, Jennifer N., Jacobson, Matthew P., Zuiderweg, Erik R. P., Gestwicki, Jason E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857975/
https://ncbi.nlm.nih.gov/pubmed/29414793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001575
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