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A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions

Allosteric inhibitors can be more difficult to optimize without an understanding of how their binding influences the conformational motions of the target. Here, we used an integrated computational and experimental approach to probe the molecular mechanism of an allosteric inhibitor of heat shock pro...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Rinaldi, Silvia, Assimon, Victoria A., Young, Zapporah T., Morra, Giulia, Shao, Hao, Taylor, Isabelle R., Gestwicki, Jason E., Colombo, Giorgio
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377810/
https://ncbi.nlm.nih.gov/pubmed/30372610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00712
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