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Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98
The heat shock protein 70 (Hsp70) family of molecular chaperones are highly expressed in tumors. Inhibitors containing a pyridinium-modified benzothiazole, such as JG-98, bind to a conserved, allosteric site in Hsp70, showing promising anti-proliferative activity in cancer cells. When bound to Hsp70...
Shranjeno v:
| izdano v: | Bioorg Med Chem Lett |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205417/ https://ncbi.nlm.nih.gov/pubmed/31952963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.126954 |
| Oznake: |
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