Alpha9 nicotinic acetylcholine receptors and the treatment of pain

Por McIntosh, J. Michael, Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belén, Vincler, Michelle
Publicado em 2009

The Direct Actions of GABA, 2’-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABA(A) Receptors: Evidence for Receptors with Different Subunit Stoichiometries

Por Chua, Han Chow, Absalom, Nathan L., Hanrahan, Jane R., Viswas, Raja, Chebib, Mary
Publicado no PLoS One (2015)

Oxytocin prevents ethanol actions at δ subunit-containing GABA(A) receptors and attenuates ethanol-induced motor impairment in rats

Por Bowen, Michael T., Peters, Sebastian T., Absalom, Nathan, Chebib, Mary, Neumann, Inga D., McGregor, Iain S.
Publicado no Proc Natl Acad Sci U S A (2015)

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q

Por Yow, Tin T, Pera, Elena, Absalom, Nathan, Heblinski, Marika, Johnston, Graham AR, Hanrahan, Jane R, Chebib, Mary
Publicado em 2011

Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism

Por Naffaa, Moawiah M., Absalom, Nathan, Solomon, V. Raja, Chebib, Mary, Hibbs, David E., Hanrahan, Jane R.
Publicado no PLoS One (2016)

Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State

Por Indurthi, Dinesh C., Lewis, Trevor M., Ahring, Philip K., Balle, Thomas, Chebib, Mary, Absalom, Nathan L.
Publicado no PLoS One (2016)

Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABA(A) receptors: evidence of a novel benzodiazepine site in the α1-α1 interface

Por Che Has, Ahmad Tarmizi, Absalom, Nathan, van Nieuwenhuijzen, Petra S., Clarkson, Andrew N., Ahring, Philip K., Chebib, Mary
Publicado no Sci Rep (2016)

Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABA(C) ρ(1) Receptors

Por Yamamoto, Izumi, Absalom, Nathan, Carland, Jane E., Doddareddy, Munikumar R., Gavande, Navnath, Johnston, Graham A. R., Hanrahan, Jane R., Chebib, Mary
Publicado em 2012

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABA(A) Receptors: Functional Characteristics and Molecular Mechanism

Por Chua, Han Chow, Christensen, Emilie T. H., Hoestgaard-Jensen, Kirsten, Hartiadi, Leonny Y., Ramzan, Iqbal, Jensen, Anders A., Absalom, Nathan L., Chebib, Mary
Publicado no PLoS One (2016)

Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the ρ(1) Receptor

Por Yamamoto, Izumi, Carland, Jane E., Locock, Katherine, Gavande, Navnath, Absalom, Nathan, Hanrahan, Jane R., Allan, Robin D., Johnston, Graham A. R., Chebib, Mary
Publicado em 2012

Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric dependent action of the α-conotoxin, Vc1.1

Por Indurthi, Dinesh C., Pera, Elena, Kim, Hye-Lim, Chu, Cindy, McLeod, Malcolm D., McIntosh, J. Michael, Absalom, Nathan L., Chebib, Mary
Publicado no Biochem Pharmacol (2014)

Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor: ANTAGONIST BINDING SITE AND MODE OF RECEPTOR INHIBITION REVEALED

Por Absalom, Nathan L., Quek, Gracia, Lewis, Trevor M., Qudah, Taima, von Arenstorff, Ida, Ambrus, Joseph I., Harpsøe, Kasper, Karim, Nasiara, Balle, Thomas, Mcleod, Malcolm D., Chebib, Mary
Publicado em 2013

Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors

Por Quek, Gracia X. J., Lin, Diana, Halliday, Jill I., Absalom, Nathan, Ambrus, Joseph I., Thompson, Andrew J., Lochner, Martin, Lummis, Sarah C. R., McLeod, Malcolm D., Chebib, Mary
Publicado em 2010

α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

Por Absalom, Nathan, Eghorn, Laura F., Villumsen, Inge S., Karim, Nasiara, Bay, Tina, Olsen, Jesper V., Knudsen, Gitte M., Bräuner-Osborne, Hans, Frølund, Bente, Clausen, Rasmus P., Chebib, Mary, Wellendorph, Petrine
Publicado em 2012

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

Por Goldsworthy, Michelle, Absalom, Nathan L., Schröter, David, Matthews, Helen C., Bogani, Debora, Moir, Lee, Long, Anna, Church, Christopher, Hugill, Alison, Anstee, Quentin M., Goldin, Rob, Thursz, Mark, Hollfelder, Florian, Cox, Roger D.
Publicado em 2013