Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two se...

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Detaylı Bibliyografya
Asıl Yazarlar: Goldsworthy, Michelle, Absalom, Nathan L., Schröter, David, Matthews, Helen C., Bogani, Debora, Moir, Lee, Long, Anna, Church, Christopher, Hugill, Alison, Anstee, Quentin M., Goldin, Rob, Thursz, Mark, Hollfelder, Florian, Cox, Roger D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691224/
https://ncbi.nlm.nih.gov/pubmed/23826075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061870
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