Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two se...

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Detalhes bibliográficos
Main Authors: Goldsworthy, Michelle, Absalom, Nathan L., Schröter, David, Matthews, Helen C., Bogani, Debora, Moir, Lee, Long, Anna, Church, Christopher, Hugill, Alison, Anstee, Quentin M., Goldin, Rob, Thursz, Mark, Hollfelder, Florian, Cox, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691224/
https://ncbi.nlm.nih.gov/pubmed/23826075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061870
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