Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

OBJECTIVES— To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS— Haploinsufficiency of the insulin receptor and associated mild insulin resistance has been used to sensitize an N-ethyl-N-nitrosourea...

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Detalhes bibliográficos
Main Authors: Goldsworthy, Michelle, Hugill, Alison, Freeman, Helen, Horner, Emma, Shimomura, Kenju, Bogani, Debora, Pieles, Guido, Mijat, Vesna, Arkell, Ruth, Bhattacharya, Shoumo, Ashcroft, Frances M., Cox, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494690/
https://ncbi.nlm.nih.gov/pubmed/18477811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-0337
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