Insulin secretion from beta cells is affected by deletion of Nicotinamide Nucleotide Transhydrogenase

NNT is an inner mitochondrial membrane transmembrane protein involved in regenerating NADPH, coupled with proton translocation across the inner membrane. We have shown that a defect in NNT function in the mouse, and specifically within the beta cell, leads to a reduction in insulin secretion. This c...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Shimomura, Kenju, Galvanovskis, Juris, Goldsworthy, Michelle, Hugill, Alison, Kaizak, Stephan, Lee, Angela, Meadows, Nicholas, Quwailid, Mohamed Mohideen, Rydström, Jan, Teboul, Lydia, Ashcroft, Fran, Cox, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890886/
https://ncbi.nlm.nih.gov/pubmed/19426883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0076-6879(09)05025-3
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