Insulin secretion from beta cells is affected by deletion of Nicotinamide Nucleotide Transhydrogenase

NNT is an inner mitochondrial membrane transmembrane protein involved in regenerating NADPH, coupled with proton translocation across the inner membrane. We have shown that a defect in NNT function in the mouse, and specifically within the beta cell, leads to a reduction in insulin secretion. This c...

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Publicado en:Methods Enzymol
Main Authors: Shimomura, Kenju, Galvanovskis, Juris, Goldsworthy, Michelle, Hugill, Alison, Kaizak, Stephan, Lee, Angela, Meadows, Nicholas, Quwailid, Mohamed Mohideen, Rydström, Jan, Teboul, Lydia, Ashcroft, Fran, Cox, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890886/
https://ncbi.nlm.nih.gov/pubmed/19426883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0076-6879(09)05025-3
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