Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors

[Image: see text] Neuronal nicotinic acetylcholine receptors (nAChR) are ligand gated ion channels that mediate fast synaptic transmission. Methyllycaconitine (MLA) is a selective and potent antagonist of the α7 nAChR, and its anthranilate ester side-chain is important for its activity. Here we repo...

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Detalhes bibliográficos
Main Authors: Quek, Gracia X. J., Lin, Diana, Halliday, Jill I., Absalom, Nathan, Ambrus, Joseph I., Thompson, Andrew J., Lochner, Martin, Lummis, Sarah C. R., McLeod, Malcolm D., Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368652/
https://ncbi.nlm.nih.gov/pubmed/22778816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100073x
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