Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor: ANTAGONIST BINDING SITE AND MODE OF RECEPTOR INHIBITION REVEALED

The α4β2 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the brain and are implicated in a variety of physiological processes. There are two stoichiometries of the α4β2 nAChR, (α4)(2)(β2)(3) and (α4)(3)(β2)(2,) with different sensitivities to acetylcholine (ACh), but their pharmac...

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Detalhes bibliográficos
Main Authors: Absalom, Nathan L., Quek, Gracia, Lewis, Trevor M., Qudah, Taima, von Arenstorff, Ida, Ambrus, Joseph I., Harpsøe, Kasper, Karim, Nasiara, Balle, Thomas, Mcleod, Malcolm D., Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772200/
https://ncbi.nlm.nih.gov/pubmed/23893416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475053
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