Rational Design of α-Conotoxin Analogues Targeting α7 Nicotinic Acetylcholine Receptors: IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that belong to the superfamily of Cys loop receptors. Valuable insight into the orthosteric ligand binding to nAChRs in recent years has been obtained from the crystal structures of acetylcholine-binding proteins (AChBPs) that...

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Bibliografiset tiedot
Päätekijät: Armishaw, Christopher, Jensen, Anders A., Balle, Thomas, Clark, Richard J., Harpsøe, Kasper, Skonberg, Christian, Liljefors, Tommy, Strømgaard, Kristian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Membrane Transport, Structure, Function, and Biogenesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666602/
https://ncbi.nlm.nih.gov/pubmed/19131337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806136200
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