A Synthetic Combinatorial Strategy for Developing α-Conotoxin Analogs as Potent α(7) Nicotinic Acetylcholine Receptor Antagonists

α-Conotoxins are peptide neurotoxins isolated from venomous cone snails that display exquisite selectivity for different subtypes of nicotinic acetylcholine receptors (nAChR). They are valuable research tools that have profound implications in the discovery of new drugs for a myriad of neuropharmaco...

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Detalhes bibliográficos
Main Authors: Armishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A., Jensen, Anders A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804339/
https://ncbi.nlm.nih.gov/pubmed/19901032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071183
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