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Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library
[Image: see text] α-Conotoxins are disulfide-rich peptide neurotoxins that selectively inhibit neuronal nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR subtype has been identified as a novel target for managing nicotine addiction. Using a mixture-based positional-scanning synthetic combin...
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| 發表在: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2014
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358631/ https://ncbi.nlm.nih.gov/pubmed/24649848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500183r |
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