Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

[Image: see text] α-Conotoxins are disulfide-rich peptide neurotoxins that selectively inhibit neuronal nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR subtype has been identified as a novel target for managing nicotine addiction. Using a mixture-based positional-scanning synthetic combin...

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Vydáno v:J Med Chem
Hlavní autoři: Chang, Yi-Pin, Banerjee, Jayati, Dowell, Cheryl, Wu, Jinhua, Gyanda, Reena, Houghten, Richard A., Toll, Lawrence, McIntosh, J. Michael, Armishaw, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358631/
https://ncbi.nlm.nih.gov/pubmed/24649848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500183r
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