Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

We identified a previously unidentified conotoxin gene from Conus generalis whose precursor signal sequence has high similarity to the O1-gene conotoxin superfamily. The predicted mature peptide, αO-conotoxin GeXIVA (GeXIVA), has four Cys residues, and its three disulfide isomers were synthesized. P...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor I., Christensen, Sean, Romero, Haylie K., McIntyre, Melissa, Dowell, Cheryl, Baxter, James C., Elmslie, Keith S., Craik, David J., McIntosh, J. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522777/
https://ncbi.nlm.nih.gov/pubmed/26170295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503617112
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