Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

Por Kasheverov, Igor E., Zhmak, Maxim N., Khruschov, Alexey Y., Tsetlin, Victor I.
Publicado em 2011

Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice

Por Dyachenko, Igor A, Murashev, Arkadii N, Andreeva, Tatyana V, Tsetlin, Victor I, Utkin, Yuri N
Publicado em 2013

Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A(2) are the Main Venom Components

Por Kovalchuk, Sergey I., Ziganshin, Rustam H., Starkov, Vladislav G., Tsetlin, Victor I., Utkin, Yuri N.
Publicado no Toxins (Basel) (2016)

Isolation and preliminary crystallographic studies of two new phospholipases A(2) from Vipera nikolskii venom

Por Gao, Wei, Starkov, Vladislav G., Tsetlin, Victor I., Utkin, Yuri N., Lin, Zheng-jiong, Bi, Ru-chang
Publicado em 2005

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Por Kasheverov, Igor E., Shelukhina, Irina V., Kudryavtsev, Denis S., Makarieva, Tatyana N., Spirova, Ekaterina N., Guzii, Alla G., Stonik, Valentin A., Tsetlin, Victor I.
Publicado no Mar Drugs (2015)

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

Por Lin, Bo, Xu, Manyu, Zhu, Xiaopeng, Wu, Yong, Liu, Xi, Zhangsun, Dongting, Hu, Yuanyan, Xiang, Shi-Hua, Kasheverov, Igor E., Tsetlin, Victor I., Wang, Xinquan, Luo, Sulan
Publicado no Sci Rep (2016)

Dimeric α-Cobratoxin X-ray Structure: LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS

Por Osipov, Alexey V., Rucktooa, Prakash, Kasheverov, Igor E., Filkin, Sergey Yu., Starkov, Vladislav G., Andreeva, Tatyana V., Sixma, Titia K., Bertrand, Daniel, Utkin, Yuri N., Tsetlin, Victor I.
Publicado em 2012

Inhibition of Nicotinic Acetylcholine Receptors, a Novel Facet in the Pleiotropic Activities of Snake Venom Phospholipases A(2)

Por Vulfius, Catherine A., Kasheverov, Igor E., Starkov, Vladislav G., Osipov, Alexey V., Andreeva, Tatyana V., Filkin, Sergey Yu., Gorbacheva, Elena V., Astashev, Maxim E., Tsetlin, Victor I., Utkin, Yuri N.
Publicado no PLoS One (2014)

High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method

Por Kasheverov, Igor E., Chugunov, Anton O., Kudryavtsev, Denis S., Ivanov, Igor A., Zhmak, Maxim N., Shelukhina, Irina V., Spirova, Ekaterina N., Tabakmakher, Valentin M., Zelepuga, Elena A., Efremov, Roman G., Tsetlin, Victor I.
Publicado no Sci Rep (2016)

Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors

Por Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Paramonov, Alexander S., Chugunov, Anton O., Janickova, Helena, Dolejsi, Eva, Dolezal, Vladimir, Utkin, Yuri N., Tsetlin, Victor I., Arseniev, Alexander S., Efremov, Roman G., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Publicado no J Biol Chem (2015)

Azemiopsin from Azemiops feae Viper Venom, a Novel Polypeptide Ligand of Nicotinic Acetylcholine Receptor

Por Utkin, Yuri N., Weise, Christoph, Kasheverov, Igor E., Andreeva, Tatyana V., Kryukova, Elena V., Zhmak, Maxim N., Starkov, Vladislav G., Hoang, Ngoc Anh, Bertrand, Daniel, Ramerstorfer, Joachim, Sieghart, Werner, Thompson, Andrew J., Lummis, Sarah C. R., Tsetlin, Victor I.
Publicado em 2012

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

Por Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Kudryavtsev, Denis, Bychkov, Maxim L., Kulbatskii, Dmitrii S., Kasheverov, Igor E., Astapova, Maria V., Feofanov, Alexey V., Thomsen, Morten S., Mikkelsen, Jens D., Shenkarev, Zakhar O., Tsetlin, Victor I., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Publicado no PLoS One (2016)

NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1

Por Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Mineev, Konstantin S., D'Hoedt, Dieter, Kasheverov, Igor E., Filkin, Sergey Yu., Krivolapova, Alexandra P., Janickova, Helena, Dolezal, Vladimir, Dolgikh, Dmitry A., Arseniev, Alexander S., Bertrand, Daniel, Tsetlin, Victor I., Kirpichnikov, Mikhail P.
Publicado em 2011

Water-soluble LYNX1 Residues Important for Interaction with Muscle-type and/or Neuronal Nicotinic Receptors

Por Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Buldakova, Svetlana L., Kasheverov, Igor E., Shenkarev, Zakhar O., Reshetnikov, Roman V., Filkin, Sergey Y., Kudryavtsev, Denis S., Ojomoko, Lucy O., Kryukova, Elena V., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P., Bregestovski, Piotr D., Tsetlin, Victor I.
Publicado em 2013

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

Por Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor I., Christensen, Sean, Romero, Haylie K., McIntyre, Melissa, Dowell, Cheryl, Baxter, James C., Elmslie, Keith S., Craik, David J., McIntosh, J. Michael
Publicado no Proc Natl Acad Sci U S A (2015)

Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors

Por Kudryavtsev, Denis S., Shelukhina, Irina V., Son, Lina V., Ojomoko, Lucy O., Kryukova, Elena V., Lyukmanova, Ekaterina N., Zhmak, Maxim N., Dolgikh, Dmitry A., Ivanov, Igor A., Kasheverov, Igor E., Starkov, Vladislav G., Ramerstorfer, Joachim, Sieghart, Werner, Tsetlin, Victor I., Utkin, Yuri N.
Publicado no J Biol Chem (2015)

From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design

Publicado em 2020