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Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica. Based on computer modeling and the X-ray structure of t...

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Detalhes bibliográficos
Main Authors: Kasheverov, Igor E., Zhmak, Maxim N., Khruschov, Alexey Y., Tsetlin, Victor I.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210602/
https://ncbi.nlm.nih.gov/pubmed/22072993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md9101698
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