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Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica. Based on computer modeling and the X-ray structure of t...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Molecular Diversity Preservation International
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210602/ https://ncbi.nlm.nih.gov/pubmed/22072993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md9101698 |
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