Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models

&#945;-Conotoxins from <i>Conus</i> snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). &#945;-Conotoxin RgIA and &#945;O-conotoxin GeXIVA, blocking neuronal &#945;9&#945;10 nAChR, are potential analgesics. Typically, &...

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Detalhes bibliográficos
Main Authors: Elena V. Kryukova, Igor A. Ivanov, Dmitry S. Lebedev, Ekaterina N. Spirova, Natalia S. Egorova, Marios Zouridakis, Igor E. Kasheverov, Socrates J. Tzartos, Victor I. Tsetlin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-11-01
Colecção:Marine Drugs
Assuntos:
conotoxins
nicotinic acetylcholine receptors
ligand-binding domain
acetylcholine-binding protein
binding site
radioligand analysis
Acesso em linha:https://www.mdpi.com/1660-3397/16/12/460
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