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Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites

Diverse ligands of the muscle nicotinic acetylcholine receptor (nAChR) are used as muscle relaxants during surgery. Although a plethora of such molecules exists in the market, there is still a need for new drugs with rapid on/off-set, increased selectivity, and so forth. We found that pyrroloiminoqu...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Kudryavtsev, Denis S., Spirova, Ekaterina N., Shelukhina, Irina V., Son, Lina V., Makarova, Yana V., Utkina, Natalia K., Kasheverov, Igor E., Tsetlin, Victor I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923396/
https://ncbi.nlm.nih.gov/pubmed/29597332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16040109
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