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In vitro and in vivo characterization of a novel negative allosteric modulator of neuronal nAChRs
In this study, we compared the in vitro and in vivo neuronal nicotinic acetylcholine receptor (nAChR) properties of 1,2,3,3a,4,8b-hexahydro-2-benzyl-6-N,N-dimethylamino-1-methylindeno[1,2,-b]pyrrole (HDMP, 4) to that of negative allosteric modulator (NAM), PCP. Patch-clamp experiments showed that HD...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998338/ https://ncbi.nlm.nih.gov/pubmed/20633568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.07.006 |
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