In vitro and in vivo characterization of a novel negative allosteric modulator of neuronal nAChRs

In this study, we compared the in vitro and in vivo neuronal nicotinic acetylcholine receptor (nAChR) properties of 1,2,3,3a,4,8b-hexahydro-2-benzyl-6-N,N-dimethylamino-1-methylindeno[1,2,-b]pyrrole (HDMP, 4) to that of negative allosteric modulator (NAM), PCP. Patch-clamp experiments showed that HD...

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Bibliographic Details
Main Authors: Abdrakhmanova, Galya R., Blough, Bruce E., Nesloney, Carey, Navarro, Hernán A., Damaj, M. Imad, Carroll, F. Ivy
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998338/
https://ncbi.nlm.nih.gov/pubmed/20633568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.07.006
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