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3’-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for α4β2 versus α3β4 nAChRs
The analog of epibatidine having a fluoro- substituent at the 3’ position of the pyridine ring has been recently developed and shown to possess binding affinity in the pM range to α4β2 nAChRs and in the nM range to α7 nAChRs and to exhibit potent agonist activity in nicotine-induced analgesia tests....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669717/ https://ncbi.nlm.nih.gov/pubmed/18775444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.08.007 |
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