α(7)-nAChR-mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis

Controlled clinical trials of nicotine transdermal patch for treatment of ulcerative colitis have been shown to improve histological and global clinical scores of colitis. Here we report that nicotine (1 μM) suppresses in vitro hyperexcitability of colonic dorsal root ganglia (DRG) (L(1)–L(2)) neuro...

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Detalhes bibliográficos
Main Authors: Abdrakhmanova, Galya R., AlSharari, Shakir, Kang, Minho, Damaj, M. Imad, Akbarali, Hamid I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950695/
https://ncbi.nlm.nih.gov/pubmed/20595621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00175.2010
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