The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

The α7 nicotinic acetylcholine receptor (nAChR) is a promising drug target for a number of neurological disorders including chronic pain and inflammatory diseases. Since α7 can function as a ligand-gated ion channel, drug development initially focused on ligands that were selective activators of the...

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Detaylı Bibliyografya
Yayımlandı:Neuropharmacology
Asıl Yazarlar: Papke, Roger L., Bagdas, Deniz, Kulkarni, Abhijit R., Gould, Timothy, AlSharari, Shakir D., Thakur, Ganesh A., Damaj, M. Imad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312719/
https://ncbi.nlm.nih.gov/pubmed/25497451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.12.002
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