The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

BACKGROUND AND PURPOSE: Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago‐PAMs, add further regulatio...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Bagdas, Deniz, Wilkerson, Jenny L, Kulkarni, Abhijit, Toma, Wisam, AlSharari, Shakir, Gul, Zulfiye, Lichtman, Aron H, Papke, Roger L, Thakur, Ganesh A, Damaj, M Imad
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959951/
https://ncbi.nlm.nih.gov/pubmed/27243753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13528
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