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Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states

BACKGROUND AND PURPOSE: GAT107 ((3aR,4S,9bS)‐4‐(4‐bromo‐phenyl)‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta‐[c]quinoline‐8‐sulfonamide) is a positive allosteric modulator (PAM) and agonist of α7 nicotinic acetylcholine receptors (nAChRs)that can cause a prolonged period of primed potentiation of acetylcholin...

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Xehetasun bibliografikoak
Argitaratua izan da:Br J Pharmacol
Egile Nagusiak: Papke, Roger L, Stokes, Clare, Damaj, M Imad, Thakur, Ganesh A, Manther, Khan, Treinin, Millet, Bagdas, Deniz, Kulkarni, Abhijit R, Horenstein, Nicole A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979752/
https://ncbi.nlm.nih.gov/pubmed/28477386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13851
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